Since 1999, the opioid epidemic has been US public health crisis #1. In 2020, that changed. While the focus on COVID-19 was warranted, many argue that we have taken multiple steps back in our battle against the overuse and abuse of opioids. During PAINWeek last year, this course presented the multiple new challenges that pain practitioners face due to the COVID-19 epidemic. This year, as we are moving into the endemic stage, discussed will be whether we should transition our priorities back to opioids, what are the effects of COVID-19 on mental health, and the challenges that long COVID may present in the future.