This course will explore painful neuromusculoskeletal conditions affecting the upper limb. It will review the most common neuromusculoskeletal conditions seen in an outpatient setting, providing primary care and specialists alike a solid foundation of practical knowledge to evaluate and manage these common complaints, including cervical radiculopathy, focal entrapment syndromes, and soft-tissue pathology of the shoulder, elbow, wrist, and hand. Using clinical scenarios and illustrative cases, we’ll review the key components of the history and physical exam and relevant anatomy along with recommended diagnostic testing. Alternative diagnoses and clinical pearls will also be discussed, emphasizing important diagnostic tests necessary to differentiate conditions. Cases will be followed by practical, up-to-date, evidence-based management recommendations.