There are numerous pharmacotherapeutic options to treat neuropathic pain. If 1st line medications fail, however, providers often feel uncomfortable with these options and hesitate to offer them to patients who might benefit. This session will review many 2nd & 3rd line agents and highlight where the evidence exists, dosing targets, titration schedules, drug interactions, and adverse effects. Learners will benefit from discussion, examples, and reference materials methods to incorporate into their practice to use every day.