Patients receiving palliative or hospice care frequently experience nausea and/or vomiting, dysphagia, gastrointestinal obstruction, and fluctuating levels of consciousness that make oral administration challenging. In this presentation, participants will learn to identify alternate routes of medication administration commonly utilized in this patient population, such as transmucosal, transdermal, topical, and rectal, and the benefits and limitations associated with these routes. The use of compounded topical medications will also be addressed, including a discussion of the available evidence either supporting of refuting their use.